Dearomatization of tryptophols via a vanadium-catalyzed asymmetric epoxidation and ring-opening cascade.
نویسندگان
چکیده
An enantioselective epoxidation of tryptophols followed by an intramolecular epoxide opening reaction was realized by chiral vanadium catalysts derived from C2 symmetric bis-hydroxamic acid (BHA) ligands. 3a-Hydroxyfuroindoline derivatives with up to 89% yield and 90% ee were obtained under mild reaction conditions.
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عنوان ژورنال:
- Chemical communications
دوره 50 10 شماره
صفحات -
تاریخ انتشار 2014